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Subsections
The lateral hypothalamus has both Glutamatergic and GABAergic neurons (
Stanley et al., 2011).
The strongest outputs from the LH are to the VTA and the lateral
Habenula (LHb) (
Stuber and Wise, 2016). The projection from the LH to the
Habenula is excitatory (
Poller et al., 2013) which in turn then projects
to the RMTg which has GABA-ergic neurons.
The LH contains both GLU and GABA neurons where the GLU neurons
project to the DA neurons in the VTA whereas the GABA neurons in the
LH project to the GABA neurons in the VTA which in turn then
disinhibit DA neurons in the VTA.
The LH receives many different inputs from different cortical and
subcortical areas which are both excitatory and inhibitory. The PFC
seems to be an import source of excitatory information, in particular
the mPFC. It also receives inputs from the extended Amygdala and the
hippocampus (
Stuber and Wise, 2016).
Feeding is stimulated when LH cells are activated by glutamate
agonists (
Stanley et al., 1993) and that stimulation of GABAergic cells in
the LH inhibits feeding (
Stanley et al., 2011).
