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Subsections
The newly discovered rostral medial tegmental nucleus, also called the
tail of the VTA, is partially embedded in the VTA
(
Bourdy and Barrot, 2012). It has been suggested that it has an ideal
location to function as a switch between opposing aversion and reward
responding areas and to direct information to DA neurons
(
Barrot et al., 2012).
The main afferent to the RMTg is the glutamatergic connection from the
LHb, which is 7 times stronger than the LHb projection to the VTA
(
Barrot et al., 2012) and other afferents include the VTA and SNc
(
Lavezzi and Zahm, 2011).
RMTg GABA neurons differ in their targets to the VTA GABA neurons
which, for example, target the forebrain in large numbers
(Barrot et al., 2012).
The RMTg’s GABA efferents are the principal inhibitory connection to
the VTA and SNc and play a critical role in RPE and aversive
signalling (
Bourdy and Barrot, 2012). The RMTg also sends projections to
other neuromodulatory systems including the Raphe nucleus and the
locus ceruleus (
Barrot et al., 2012) (
Hong et al., 2011).
