Pan: Drag the map with the mouse. Zoom: Press the ALT-key and turn the mouse-wheel.
Subsections
The m-PFC is considered by Homberg to be the most important location
for top level cognitive functions.
The ventral portion of the m-PFC is called infralimbic cortex (IL)
(Tsutsui-Kimura et al., 2016).
A well known target of the mPFC is the Nacc core where the Nacc seems
to be taking the role for response inhibition and waiting
(
Feja et al., 2014;
Neufang et al., 2016).
Projections from the m-PFC to the DRN allowing the m-PFC to regulate
5HT firing and therefore control its own 5HT innervation
(Homberg, 2012; Juckel et al., 1999). This projection is inhibitory
(see also the DRN page).
5HT plays a significant role in the mPFC which has been shown in great
detail in (
Santana and Artigas, 2017) and concluded that 5-HT1A, 5-HT2A,
5-HT2C, and 5-HT3, dopamine D1 and D2 are widely expressed in the
mPFC. The receptor 5-HT3 was only expressed on GABAergic interneurons
while all the other ones were expressed on both pyramidal and
interneurons.
Lesions to the IL causes more impulsive behaviour
(
Tsutsui-Kimura et al., 2016) and reduction in 5HT is also associated
with less impulse control (
Neufang et al., 2016).
